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Treatment did not fundamentally change until antibiotics arrived on the scene.
In a world without antibiotics, many peoples’ UTIs would doubtless subside under attack from the immune system.
Scientists tracking UTIs from 2000 to 2010 found a dramatic uptick in cases caused by resistant to the drug trimethoprim-sulfame-thoxazole jumped from 17.9% to 24.2%.
These are two of the most commonly prescribed antibiotics used to treat UTIs.
But some fraction of them would not, and those people would find themselves in dire straits.