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Lahn's own calculations acknowledge that the microcephalin variant could have arisen anywhere from 14,000 to 60,000 years ago, and that the uncertainty about the ASPM variant ranged from 500 to 14,000 years ago.Those criticisms are particularly important, Collins said, because Lahn's testing did find geographic differences in populations harboring the gene variants today.

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For ASPM, the variation arose about 5,800 years ago, roughly correlating with the development of written language, spread of agriculture and development of cities, he said.

"The genetic evolution of humans in the very recent past might in some ways be linked to the cultural evolution," he said.

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Francis Collins, director of the National Human Genome Research Institute.